Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
ACKR1 or DARC is an atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades resulting instead in chemokine sequestration, degradation, or transcytosis. ACKR1 is also known as an interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. It has a promiscuous chemokine-binding profile by interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. ACKR1 also acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and for the malaria parasites P.vivax and P.knowlesi.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Atypical chemokine receptor 1; CD234; CD234 antigen; CTA-134P22.3; Duffy Antigen; Duffy antigen receptor for chemokines; Duffy antigen/chemokine receptor; Duffy blood group, atypical chemokine receptor; Duffy blood group, chemokine receptor; Fy Antigen; FYDuffy blood group; glycoprotein D; GPDWBCQ1; HGNC:4035; OTTHUMP00000060081
Gene Aliases: AA162249; Ackr1; CCBP1; CD234; Darc; Dfy; ESTM35; FY; GPD
UniProt ID: (Mouse) Q9QUI6
Molecular Function: transmembrane signal receptor