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      DARPP-32 Polyclonal Antibody

      See 10 other DARPP-32 antibodies ›
      DARPP-32 Polyclonal Antibody for Western Blot and IHC

      Catalog#: PA1-4650 Invitrogen

      Catalog # Size Price (USD) Qty Datasheet
      PA1-4650 100 µL
      309.00
      Please enter a quantity in the range of 1 to 199.
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      Product Details

      Bioinformatics

      Documents
      Details
      Tested species reactivity Rat
      Host / Isotype Rabbit / IgG
      Class Polyclonal
      Type Antibody
      Immunogen Synthetic peptide corresponding to the N-terminal region of rat PPP1R1B conjugated to KLH
      Conjugate Unconjugated
      Form Liquid
      Purification Affinity chromatography
      Storage buffer 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol
      Contains no preservative
      Storage Conditions -20° C, Avoid Freeze/Thaw Cycles
      Tested Applications Dilution *
      Immunohistochemistry (IHC) 1:250
      Western Blot (WB) 1:1000

      * Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.

      Product Specific Information

      This antibody is predicted to react with bovine, canine, chicken, human, mouse, non-human primate and Xenopus based on 100% sequence homology.

      This antibody is specific for the ~32 kDa DARPP-32 protein.

      Background/Target Information

      DARPP-32 is a dopamine (DA) and AMP-regugated ~32 kDa phosphoprotein that is associated with dopaminoceptive neurons (Fienberg et al., 1998). The protein inhibits Protein Phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA (Bibb et al., 1999). Phosphorylation of DARPP-32 is thought to play a critical role in the regugation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac® (Maldve et al., 2002; Lindskog et al., 2002; Svenningsson et al., 2002).

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      Documents

      Material safety data sheets (MSDS)

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