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Product Details
PA5-36337
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 154-198 of human Dio-1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2553478
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 244 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Dio-1 (Death Inducer-Obliterator-1) is a putative transcription factor that contains two zinc finger motifs. Dio-1 translocates to the nucleus, and activates apoptosis during limb development. Programmed cell death, a highly regulated form of apoptosis, plays an important role in determining the amount of tissue, the shape, and the definition of each digit during limb development. Dio-1 expression is upregulated when an apoptotic signal is detected, and subsequently apoptosis is induced. This process is similar to the expression of NFkB and NGF in response to external signals. Dio-1 expression is suppressed by caspase inhibitors and Bcl-2 expression. This supports the theory that Dio-1 functions in the onset of programmed cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DATF-1; death associated transcription factor 1; death inducer-obliterator-2; death inducer-obliterator-3; Death-associated transcription factor 1; Death-inducer obliterator 1; DIO-1
Gene Aliases: 6720461J16Rik; BYE1; C20orf158; D130048F08Rik; DATF-1; DATF1; dido; DIDO1; DIDO2; DIDO3; DIO-1; DIO1; dJ885L7.8; KIAA0333
UniProt ID: (Human) Q9BTC0, (Mouse) Q8C9B9
Entrez Gene ID: (Human) 11083, (Mouse) 23856, (Rat) 362286
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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