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Invitrogen

DAXX Polyclonal Antibody

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DAXX Polyclonal Antibody

Product Details

PA5-79136

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunocytochemistry (ICC/IF)

5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human Daxx (325-341aa QERRHLDLIYNFGCHLT).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2746252

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human Hela whole cell, human Ramos whole cell, human MCF-7 whole cell, human Jurkat whole cell, rat testis tissue, mouse testis tissue. ICC/IF: U2OS cell.

Target Information

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CENP-C binding protein; DADB-159G18.9; DAXX; Death domain-associated protein 6; death domain-binding protein; HDaxx; death-associated protein 6; death-domain associated protein; EAP1; ETS1-associated protein 1; Fas death domain-associated protein; Fas-binding protein; hDaxx; MGC126245; MGC126246; SMIM40; unnamed protein product

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Gene Aliases: BING2; DAP6; DAXX; EAP1; SMIM40

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UniProt ID: (Human) Q9UER7, (Mouse) O35613

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Entrez Gene ID: (Human) 1616, (Mouse) 13163, (Rat) 140926

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Function(s)
p53 binding transcription coactivator activity transcription corepressor activity protein binding enzyme binding protein kinase binding protein kinase activator activity heat shock protein binding ubiquitin protein ligase binding histone binding protein homodimerization activity androgen receptor binding RNA polymerase II sequence-specific DNA binding transcription factor binding transcription regulator inhibitor activity molecular condensate scaffold activity transcription factor binding protein N-terminus binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter mitotic cytokinesis positive regulation of protein phosphorylation nucleosome assembly chromatin remodeling transcription, DNA-templated regulation of transcription, DNA-templated apoptotic process negative regulation of myotube differentiation chromatin modification androgen receptor signaling pathway PML body organization regulation of protein ubiquitination positive regulation of histone phosphorylation positive regulation of apoptotic process positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter apoptotic signaling pathway positive regulation of neuron death negative regulation of nucleic acid-templated transcription positive regulation of apoptotic signaling pathway chromatin organization JNK cascade extrinsic apoptotic signaling pathway via death domain receptors regulation of gene expression negative regulation of gene expression cellular response to heat cellular response to unfolded protein neuron intrinsic apoptotic signaling pathway in response to oxidative stress regulation of apoptotic process positive regulation of transcription, DNA-templated cellular response to cadmium ion cellular response to copper ion cellular response to diamide cellular response to sodium arsenite response to metal ion cellular response to tumor necrosis factor cellular response to anoxia
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