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Invitrogen
DAZL Polyclonal Antibody
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Product Details
PA5-18404
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Goat,
Pig
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (GNGPQKKSVDR) corresponding to the internal amino acids of DAZL (aa 240-250).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, canine and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
Protein expression pattern show that DAZL is involved in mitosis and meiosis of human germ cell. The DAZL gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females.The protein is expressed in germ cells of diverse mammalian species. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In humans, DAZL is expressed in primordial germ cells, adult testis, and the ovary. It plays a central role during spermatogenesis. Defects in DAZL may cause infertility due to severe oligozoospermia (az) and non obstructive azoospermia. The concentrations of DAZL transcripts were lower in men with spermatogenic failure. Drosophila and mouse mutants that have lost DAZ homologous gene function found to be azoospermic, just as with human azoospermia DAZ. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: an autosomal gene similar to the azoospermia factor candidate gene DAZ on the Y chromosome; DAZ homolog; DAZ like-1 autosomal; DAZ-like autosomal; deleted in azoospermia protein 3; Deleted in azoospermia-like; Deleted in azoospermia-like 1; germline specific RNA binding protein; HGNC:2685; MGC26406; spermatogenesis gene on the Y-like autosomal; SPGY-like-autosomal; testis secretory sperm-binding protein Li 204a; unnamed protein product
Gene Aliases: DAZH; DAZL; DAZL1; DAZLA; SPGYLA
UniProt ID: (Human) Q92904
Entrez Gene ID: (Human) 1618, (Rat) 680486
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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