Search
Invitrogen
DBC1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 4
DBC1 Antibody (PA5-121069) in IHC (P)
Immunohistochemistry analysis of DBC1 in paraffin-embedded human rectal cancer. Samples were incubated with DBC1 Polyclonal antibody (Product # PA5-121069) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-121069
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 654-923 of human CCAR2 (NP_066997.3).
Conjugate
Form
Liquid
Concentration
0.48 mg/mL
Amount
48 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: Jurkat, HeLa, Rat lung. The target is usually found in the following locations: Cytoplasm, Nucleus.
Immunogen sequence: LLRDDGEEEF AGAKLEDSEV RSVASNQSEM EFSSLQDMPK ELDPSAVLPL DCLLAFVFFD ANWCGYLHRR DLERILLTLG IRLSAEQAKQ LVSRVVTQNI CQYRSLQYSR QEGLDGGLPE EVLFGNLDLL PPPGKSTKPG AAPTEHKALV SHNGSLINVG SLLQRAEQQD SGRLYLENKI HTLELKLEES HNRFSATEVT NKTLAAEMQE LRVRLAEAEE TARTAERQKS QLQRLLQELR RRLTPLQLEI QRVVEKADSW VEKEEPAPSN
Target Information
DBC1 is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Cell cycle and apoptosis regulator protein 2; Cell division cycle and apoptosis regulator protein 2; DBC-1; DBC.1; DBCCR1; DBIRD complex subunit KIAA1967; deleted in breast cancer 1; Deleted in breast cancer gene 1 protein; FAM5A; NET35; p30 DBC; putative protein from MH0802201; unnamed protein product
Gene Aliases: 2610301G19Rik; CCAR2; DBC-1; DBC1; KIAA1967; mKIAA1967; NET35; p30 DBC; p30DBC; RGD1309922
UniProt ID: (Human) Q8N163, (Mouse) Q8VDP4
Entrez Gene ID: (Human) 57805, (Mouse) 219158, (Rat) 306007
regulation of transcription, DNA-templated
mRNA processing
apoptotic process
cellular response to DNA damage stimulus
RNA splicing
response to UV
Wnt signaling pathway
negative regulation of cell growth
regulation of protein stability
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of DNA-templated transcription, elongation
regulation of circadian rhythm
positive regulation of apoptotic process
negative regulation of catalytic activity
mitochondrial fragmentation involved in apoptotic process
negative regulation of transcription, DNA-templated
rhythmic process
positive regulation of canonical Wnt signaling pathway
regulation of protein deacetylation
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
positive regulation of DNA damage checkpoint
cell cycle
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support