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Invitrogen
DCC Polyclonal Antibody
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Product Details
PA5-111414
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human DCC. Recombinant protein control fragment (Product #RP-106629).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GDIGIYRCSA RNPASSRTGN EAEVRILSDP GLHRQLYFLQ RPSNVVAIEG KDAVLECCVS GYPPPSFTWL RGEEVIQLRS KKYSLLGGSN
Highest antigen sequence indentity to the following orthologs: Rat - 96%, Mouse - 96%.
Target Information
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Colorectal cancer suppressor; colorectal tumor suppressor (put.); putative; deleted in colorectal carcinoma; Immunoglobulin superfamily DCC subclass member 1; Netrin receptor DCC; putative colorectal tumor suppressor; Tumor suppressor protein DCC; unnamed protein product
Gene Aliases: CRC18; CRCR1; DCC; HGPPS2; IGDCC1; MRMV1; NTN1R1
UniProt ID: (Human) P43146
Entrez Gene ID: (Human) 1630
neuron migration
apoptotic process
axonogenesis
axon guidance
negative regulation of neuron projection development
spinal cord ventral commissure morphogenesis
dorsal/ventral axon guidance
anterior/posterior axon guidance
negative regulation of collateral sprouting
cell-cell adhesion
postsynaptic modulation of chemical synaptic transmission
negative regulation of dendrite development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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