DCD is a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients.
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Protein Aliases: AIDD; DCD; DCD-1; Dermcidin; diffusible survival/evasion peptide; DSEP; Preproteolysin; proteolysis inducing factor; survival promoting peptide; Survival-promoting peptide
Gene Aliases: AIDD; DCD; DCD-1; DSEP; HCAP; PIF
UniProt ID: (Human) P81605
Entrez Gene ID: (Human) 117159