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Invitrogen
DCK Polyclonal Antibody
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FIGURE: 1 / 11
DCK Antibody (PA5-27787) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of DCK was performed in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Green: DCK Polyclonal Antibody (Product # PA5-27787) diluted at 1:500. Red: Phalloidin, a cytoskeleton marker. Scale bar = 10 µm.
Product Details
PA5-27787
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human DCK. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.41 mg/mL
Amount
141 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, A431, HeLa, HepG2, A549, H1299, PC-12, Rat2, DCK-transfected 293T.
Predicted reactivity: Mouse (93%), Rat (92%), Chicken (82%), Rhesus Monkey (96%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DCK; Deoxyadenosine kinase; Deoxycytidine kinase; Deoxyguanosine kinase; deoxynucleoside kinase; unnamed protein product
Gene Aliases: DCK
UniProt ID: (Human) P27707, (Mouse) P43346, (Rat) P48769
Entrez Gene ID: (Human) 1633, (Mouse) 13178, (Rat) 79127
nucleotide binding
deoxyadenosine kinase activity
deoxycytidine kinase activity
deoxyguanosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
deoxynucleoside kinase activity
protein homodimerization activity
cytidine kinase activity
magnesium ion binding
drug binding
nucleoside kinase activity
pyrimidine deoxyribonucleoside binding
nucleotide kinase
nucleobase-containing compound metabolic process
pyrimidine nucleotide metabolic process
CMP biosynthetic process
dAMP salvage
carbohydrate derivative metabolic process
nucleoside phosphate biosynthetic process
deoxyribonucleoside monophosphate biosynthetic process
nucleotide biosynthetic process
phosphorylation
drug metabolic process
deoxycytidine metabolic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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