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Invitrogen
DCK Polyclonal Antibody
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FIGURE: 1 / 7
DCK Antibody (PA5-79140) in IHC (P)
Immunohistochemistry (Paraffin) analysis of DCK in paraffin-embedded section of human breast cancer tissue using DCK Polyclonal Antibody (Product # PA5-79140). Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. The tissue section was then incubated with the primary antibody at a 2 µg/mL dilution overnight at ... View More
Product Details
PA5-79140
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived human DCK recombinant protein (Position: E17-L260).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Jurkat whole cell, rat thymus tissue, mouse thymus tissue. IHC: human breast cancer tissue, human ovary cancer tissue, human tonsil tissue, mouse liver tissue, rat liver tissue. Flow: U87 cell.
Target Information
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DCK; Deoxyadenosine kinase; Deoxycytidine kinase; Deoxyguanosine kinase; deoxynucleoside kinase; unnamed protein product
Gene Aliases: DCK
UniProt ID: (Human) P27707, (Mouse) P43346, (Rat) P48769
Entrez Gene ID: (Human) 1633, (Mouse) 13178, (Rat) 79127
nucleotide binding
deoxyadenosine kinase activity
deoxycytidine kinase activity
deoxyguanosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
deoxynucleoside kinase activity
protein homodimerization activity
cytidine kinase activity
magnesium ion binding
drug binding
nucleoside kinase activity
pyrimidine deoxyribonucleoside binding
nucleotide kinase
nucleobase-containing compound metabolic process
pyrimidine nucleotide metabolic process
CMP biosynthetic process
dAMP salvage
carbohydrate derivative metabolic process
nucleoside phosphate biosynthetic process
deoxyribonucleoside monophosphate biosynthetic process
nucleotide biosynthetic process
phosphorylation
drug metabolic process
deoxycytidine metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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