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Doublecortin-like kinase (DCAMKL1)(Ser/Thr protein kinase family) is essential for proper neurogenesis, neuronal migration, and axonal wiring. DCAMKL1 is involved in a calcium-signaling pathway controlling neuronal migration in the developing brain, and participates in functions of the mature nervous system. DCAMKL1 protein shares high homology with doublecortin (DCX). DCLK, but not DCX, is highly expressed in regions of active neurogenesis in the neocortex and cerebellum. DCAMKL1 controls mitotic division by regulating spindle formation and also determines the fate of neural progenitors during cortical neurogenesis.
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Protein Aliases: Calcium/calmodulin-dependent protein kinase type I-like CPG16; CLICK-I beta; double cortin and calcium/calmodulin-dependent protein kinase-like 1; doublecortin and calcium/calmodulin-dependent protein kinase-like 1; Doublecortin domain-containing protein 3A; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1; RP11-113P14.1; Serine/threonine-protein kinase DCLK1
Gene Aliases: 1700113D08Rik; 2810480F11Rik; AI836758; Ania4; CL1; Click-I; CLICK1; Cpg16; DCAMKL1; DCDC3A; Dcl; DCLK; DCLK1; KIAA0369; mKIAA0369
UniProt ID: (Human) O15075, (Mouse) Q9JLM8, (Rat) O08875
Entrez Gene ID: (Human) 9201, (Mouse) 13175, (Rat) 83825
Molecular Function:
non-receptor serine/threonine protein kinase
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