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Rockland
DCLK3 Polyclonal Antibody
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FIGURE: 1 / 2
DCLK3 Antibody (600-401-AT2) in ICC/IF
Immunofluorescence Microscopy of DLCK3 antibody. Tissue: Human brain tissue. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: DLCK3 antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: DLCK3 is nuclear and cytoplasmic. Staining: DLCK3 as red fluorescent signal.
Product Details
600-401-AT2
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-DCLK3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide near the N-terminus of human DCLK3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
DCLK3 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK3 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK3 transcripts are present in liver and kidney, suggesting that DCLK3 may play other roles than in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CLICK-I and II-related; Click-I, -II related; CLICK-I,II-related; CLr; doublecortin and CaM kinase-like 3; Doublecortin domain-containing protein 3C; Doublecortin-like and CAM kinase-like 3; Doublecortin-like kinase 3; hCG_16695; Serine/threonine-protein kinase DCLK3
Gene Aliases: BC056929; C730036H08; CLR; DCAMKL3; DCDC3C; DCK3; DCLK3; KIAA1765
UniProt ID: (Human) Q9C098, (Mouse) Q8BWQ5
Entrez Gene ID: (Human) 85443, (Mouse) 245038
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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