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DCP Polyclonal Antibody

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DCP Polyclonal Antibody

Product Details

BS-1037R

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human DCP, amino acids 31-130.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as des-gamma-carboxy prothrombin (DCP), is an abnormal form of prothrombin produced primarily by liver tissues under conditions of vitamin K deficiency or antagonism. This immature prothrombin variant lacks sufficient coagulation activity and is prominently overexpressed in hepatocellular carcinoma (HCC) cells, serving as a crucial biomarker for screening and diagnosing HCC. PIVKA-II also appears in some cases of gastric cancer, albeit less frequently. Elevated serum levels of PIVKA-II are not exclusive to malignancies; they can also be seen in non-HCC conditions, which necessitates differential diagnostic strategies. The utility of PIVKA-II is further underscored by its ability to predict extrahepatic metastases in early HCC, supporting its role in comprehensive patient evaluation and monitoring.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: coagulation factor 2; Coagulation factor II; PIVKA-II; prepro-coagulation factor II; Protein Induced by Vitamin K Absence or Antagonist-II; Prothrombin; prothrombin B-chain; thrombin; thrombin factor II; thrombin precursor; unnamed protein product

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Gene Aliases: Cf-2; Cf2; F2; FII; PT; RPRGL2; THPH1

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UniProt ID: (Mouse) P19221, (Human) P00734

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Entrez Gene ID: (Mouse) 14061, (Rat) 29251, (Human) 2147

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Function(s)
serine-type endopeptidase activity receptor binding calcium ion binding peptidase activity thrombospondin receptor activity lipopolysaccharide binding endopeptidase activity protein binding growth factor activity heparin binding serine-type peptidase activity hydrolase activity receptor agonist activity protease serine protease protein modifying enzyme
Process(es)
positive regulation of protein phosphorylation proteolysis acute-phase response cell surface receptor signaling pathway blood coagulation positive regulation of cell proliferation regulation of cell shape response to wounding regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling response to inactivity platelet activation positive regulation of blood coagulation positive regulation of cell growth positive regulation of collagen biosynthetic process wound healing fibrinolysis negative regulation of proteolysis negative regulation of astrocyte differentiation positive regulation of release of sequestered calcium ion into cytosol regulation of cytosolic calcium ion concentration cellular response to mechanical stimulus positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of reactive oxygen species metabolic process G-protein coupled receptor signaling pathway hemostasis negative regulation of platelet activation regulation of blood coagulation negative regulation of blood coagulation positive regulation of insulin secretion positive regulation of JAK-STAT cascade regulation of body fluid levels cytolysis by host of symbiont cells positive regulation of protein kinase B signaling negative regulation of fibrinolysis antimicrobial humoral immune response mediated by antimicrobial peptide thrombin receptor signaling pathway neutrophil mediated killing of gram-negative bacterium negative regulation of cytokine production involved in inflammatory response positive regulation of protein localization to nucleus ligand-gated ion channel signaling pathway
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Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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