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Proteintech
DCP1A Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-22373
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DCP1A fusion protein Ag18027
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MEALSRAGQ EMSLAALKQH DPYITSIADL TGQVALYTFC PKANQWEKTD IEGTLFVYRR SASPYHGFTI VNRLNMHNLV EPVNKDLEFQ LHEPFLLYRN ASLSIYSIWF YDKNDCHRIA KLMADVVEEE TRRSQQAARD KQSPSQANGC SDHRPIDILE MLSRAKDEYE RNQMGDSNIS SPGLQPSTQL SNLGSTETLE EMPSGSQDKS APSGHKHLTV EELFGTSLPK EQPAVVGLDS EEMERLPGDA SQKEPNSFLP FPFEQLGGAP QSETLGVPSA AHHSVQPEIT TPVLITPASI TQSNEKHAPT YTIPLSPVLS PTLPAEAPTA QVPPSLPRNS TMMQAVKTTP R
Target Information
Signal transduction of TGF-beta superfamily members is regulated by Smad proteins. In particular, Smads influence specific gene transcription by relaying signals from the cell membrane to the nucleus. Smad4 plays an essential role in TGF-beta-induced transcriptional activation wherein phosphorylated receptor-associated Smads associate with Smad4. Furthermore, SMIF (Smad4-intereacting protein) and Smad4 complex with TGF-beta and BMP4. An increase in Smad4 concentration increases the translocation of this complex to the nucleus. SMIF and Smad4 interact directly through a EVH1/WH1 domain on SMIF and a proline-rich activation domain on Smad4. Smad4 is essential to nuclear translocation of SMIF as deletion of the Smad4-interacting domain (located in the N-terminal 100 amino acids) of SMIF eliminates TGF-beta-induced nuclear translocation of SMIF. The human SMIF gene is ubiquitously expressed and encodes a protein with a relative molecular mass of 70 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DCP1 decapping enzyme homolog A; DCP1 decapping enzyme homolog A (S. cerevisiae) isoform DCP1A_1; DCP1 decapping enzyme homolog A (S. cerevisiae) isoform DCP1A_3; DCP1 decapping enzyme homolog A (S. cerevisiae) isoform DCP1A_4; DCP1 decapping enzyme-like protein A; decapping enzyme; decapping enzyme hDcp1a; FLJ21691; MAD homolog 4 interacting transcription coactivator 1; MAD homolog 4-interacting transcription coactivator 1; mRNA-decapping enzyme 1A; putative protein product of Nbla00360; Smad4-interacting transcriptional co-activator; test2; Transcription factor SMIF; unnamed protein product
Gene Aliases: 1110066A22Rik; 4930568L04Rik; AU019772; D14Ertd817e; DCP1A; HSA275986; Mitc1; Nbla00360; RGD1561298; SMAD4IP1; SMIF
UniProt ID: (Human) Q9NPI6, (Mouse) Q91YD3
Entrez Gene ID: (Human) 55802, (Rat) 361109, (Mouse) 75901
mRNA binding
protein binding
enzyme activator activity
hydrolase activity
kinesin binding
identical protein binding
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
RNA 7-methylguanosine cap binding
enzyme regulator activity
GPI-anchor transamidase activity
transcription factor binding
coenzyme F390-A hydrolase activity
coenzyme F390-G hydrolase activity
mRNA capping factor
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
deadenylation-dependent decapping of nuclear-transcribed mRNA
deadenylation-independent decapping of nuclear-transcribed mRNA
mRNA methylguanosine-cap decapping
protein localization to cytoplasmic stress granule
regulation of catalytic activity
transforming growth factor beta receptor signaling pathway
positive regulation of transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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