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Invitrogen
DCPS Polyclonal Antibody
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Product Details
PA5-58865
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DCPS. Recombinant protein control fragment (Product #RP-97297).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QLGKRKRELD VEEAHAASTE EKEAGVGNGT CAPVRLPFSG FRLQKVLRES ARDKIIFLHG KVNEASGDGD GEDAVVILEK TPFQVEQVAQ LLTGSPE
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 82%.
Target Information
Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase; DCS-1; Decapping scavenger enzyme; heat shock-like protein 1; HINT-5; Hint-related 7meGMP-directed hydrolase; Histidine triad nucleotide-binding protein 5; Histidine triad protein member 5; homolog of C. elegans 7meGMP-directed hydrolase dcs-1; m7GpppX diphosphatase; mRNA decapping enzyme; Scavenger mRNA-decapping enzyme DcpS
Gene Aliases: ARS; DCPS; DCS1; HINT-5; HINT5; HSL1; HSPC015
UniProt ID: (Human) Q96C86
Entrez Gene ID: (Human) 28960
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
deadenylation-dependent decapping of nuclear-transcribed mRNA
cellular response to menadione
negative regulation of programmed cell death
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
mRNA cis splicing, via spliceosome
RNA phosphodiester bond hydrolysis, exonucleolytic
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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