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DCTN1 Polyclonal Antibody
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Product Details
BS-6929R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human DCTN1/Dynactin 1, amino acids 251-350.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 150 kDa dynein-associated polypeptide; DAP 150; DAP-150; DAP150; DCTN 1; DP 150; DP-150; DP150; dynactin 1 (p150, glued homolog, Drosophila); dynactin 1, retrograde axonal transport; Dynactin subunit 1; Dynactin1; HMN7B; OTTHUMP00000202491; p135; p150 glued; p150 glued homolog; p150-glued; p150glued; unnamed protein product
Gene Aliases:
AL022633; DAP-150; DCTN1; DP-150; Glued; HMND14; P135; p150; p150
UniProt ID: (Human) Q14203, (Rat) P28023, (Mouse) O08788
Entrez Gene ID: (Human) 1639, (Rat) 29167, (Mouse) 13191
establishment of mitotic spindle orientation
mitotic cell cycle
nuclear migration
nervous system development
neuromuscular junction development
centriole-centriole cohesion
ventral spinal cord development
positive regulation of microtubule polymerization
melanosome transport
microtubule anchoring at centrosome
retrograde transport, endosome to Golgi
neuromuscular process
nuclear envelope disassembly
cell division
regulation of mitotic spindle organization
motor behavior
neuron cellular homeostasis
positive regulation of microtubule nucleation
axonal transport
maintenance of synapse structure
positive regulation of neuromuscular junction development
non-motile cilium assembly
neuron projection maintenance
microtubule-based process
metabolic process
transport along microtubule
cytoplasmic microtubule organization
positive regulation of intracellular protein transport
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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