Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and moue.
Specificity of this antibody: DCTN1.
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 150 kDa dynein-associated polypeptide; DAP 150; DAP-150; DAP150; DCTN 1; DP 150; DP-150; DP150; dynactin 1 (p150, glued homolog, Drosophila); dynactin 1, retrograde axonal transport; Dynactin subunit 1; Dynactin1; HMN7B; OTTHUMP00000202491; p135; p150 glued; p150 glued homolog; p150-glued; p150glued
AL022633; DAP-150; DCTN1; DP-150; Glued; P135; p150; p150
Molecular Function: chaperone