The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kDa. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 50 kDa dynein-associated polypeptide; DCTN-50; dynactin 2 (p50); Dynactin complex 50 kDa subunit; Dynactin subunit 2; epididymis secretory protein Li 77; p50 dynamitin
Gene Aliases: DCTN2; DCTN50; DYNAMITIN; HEL-S-77; RBP50
UniProt ID: (Human) Q13561
Entrez Gene ID: (Human) 10540
Molecular Function: microtubule binding motor protein