Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MNKLKSSQK DKVRQFMIFT QSSEKTAVSC LSQNDWKLDV ATDNFFQNPE LYIRESVKGS LDRKKLEQLY NRYKDPQDEN KIGIDGIQQF CDDLALDPAS ISVLIIAWKF RAATQCEFSK QEFMDGMTEL GCDSIEKLKA QIPKMEQELK EPGRFKDFYQ FTFNFAKNPG QKGLDLEMAI AYWNLVLNGR FKFLDLWNKF LLEHHKRSIP KDTWNLLLDF STMIADDMSN YDEEGAWPVL IDDFVEFARP QIAGTKSTTV (1-259 aa encoded by BC009478)
Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. [UniProt]
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