|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 259 of Human DCUN1D1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30745 targets DCUN1D1 in WB applications and shows reactivity with Human samples.
The PA5-30745 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 259 of Human DCUN1D1.
Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DCN1, defective in cullin neddylation 1, domain containing 1; DCN1-like protein 1; DCNL1; DCUN1 domain-containing protein 1; DCUN1L1; Defective in cullin neddylation protein 1-like protein 1; RP42; RP42 homolog; SCCRO; SCRO; squamous cell carcinoma related oncogene; Squamous cell carcinoma-related oncogene; Tes3
Gene Aliases: DCNL1; DCUN1D1; DCUN1L1; RP42; SCCRO; SCRO; Tes3
UniProt ID: (Human) Q96GG9
Entrez Gene ID: (Human) 54165
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