Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MPVKKKRKS PGVAAAVAED GGLKKCKISS YCRSQPPARL ISGEEHFSSK KCLAWFYEYA GPDEVVGPEG MEKFCEDIGV EPENIIMLVL AWKLEAESMG FFTKEEWLKG MTSLQCDCTE KLQNKFDFLR SQLNDISSFK NIYRYAFDFA RDKDQRSLDI DTAKSMLALL LGRTWPLFSV FYQYLEQSKY RVMNKDQWYN VLEFSRTVHA DLSNYDEDGA WPVLLDEFVE WQKVRQTS (1-237 aa encoded by BC004169)
Conjugation of Nedd8 to a cullin protein, termed neddylation, is an evolutionarily conserved process that functions to activate the cullin-RING family E3 ubiquitin ligases, leading to increased proteasomal degradation of a wide range of substrate proteins. Cellular neddylation requires the action of DCN1 (Defective in cullin neddylation protein 1), which, in humans, consists of five homologues designated as DCNL1-5. DCUN1D5 gene encodes the 28 kDa DCUN1 domain-containing protein 5 containing a C-terminal potentiating neddylation domain. The cellular function of DCUN1D5 needs to be explored, recently, a mono-ubiquitination-mediated mechanism that governs nuclear-cytoplasmic trafficking of hDCNL1, was reported to regulate hDCNL1-dependent activation of the cullin-RING E3 ubiquitin ligases in selected cellular compartments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DCN1, defective in cullin neddylation 1, domain containing 5; DCN1-like protein 5; DCNL5; DCUN1 domain-containing protein 5; Defective in cullin neddylation protein 1-like protein 5; Squamous cell carcinoma-related oncogene 5
Gene Aliases: 3110001A18Rik; 4833420K19Rik; AW060460; D430047L21Rik; DCUN1D5; RGD1307008; SCCRO5
UniProt ID: (Human) Q9BTE7, (Rat) Q5PPL2, (Mouse) Q9CXV9
Entrez Gene ID: (Human) 84259, (Rat) 315405, (Mouse) 76863
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