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Product Details
26297-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DDHD1 fusion protein Ag23620
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MDQGRIIKNT AMMREAARKI EERHFSNHAT HVEFLPVEWR SKLTLDGDTV DSITPDKVRG LRDMLNSSAM DIMYYTSPLY RDELVKGLQQ ELNRLYSLFC SRNPDFEEKG GKVSIVSHSL GCVITYDIMT GWNPVRLYEQ LLQKEEELPD ERWMSYEERH LLDELYITKR RLKEIEERLH GLKASSMTQT PALKFKVENF FCMGSPLAVF LALRGIRPGN TGSQDHILPR EICNRLLNIF HPTDPVAYRL EPLILKRYSN ISPVQIHWYN TSNPLPYEHM KPSFLNPAKE PTSVSENEGI STIPSPVTSP VLSRRHYGES ITNIGKASIL GAASIGKGLG GMLFSRFGRS
Target Information
This gene is a member of the intracellular phospholipase A1 gene family. The protein encoded by this gene preferentially hydrolyzes phosphatidic acid. It is a cytosolic protein with some mitochondrial localization, and is thought to be involved in the regulation of mitochondrial dynamics. Overexpression of this gene causes fragmentation of the tubular structures in mitochondria, while depletion of the gene results in mitochondrial tubule elongation. Deletion of this gene in male mice caused fertility defects, resulting from disruption in the organization of the mitochondria during spermiogenesis. In humans, mutations in this gene have been associated with hereditary spastic paraplegia (HSP), also known as Strumpell-Lorrain disease, or, familial spastic paraparesis (FSP). This inherited disorder is characterized by progressive weakness and spasticity of the legs. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DDHD domain-containing protein 1; PA-PLA1; Phosphatidic acid-preferring phospholipase A1 homolog; phosphatidic acid-preferring phospholipase A1-like protein; Phospholipase DDHD1; Phospholipid sn-1 acylhydrolase; spastic paraplegia 28 (autosomal recessive)
Gene Aliases: DDHD1; KIAA1705; Mir5131; PA-PLA1; PAPLA1; SPG28
UniProt ID: (Human) Q8NEL9, (Mouse) Q80YA3
Entrez Gene ID: (Human) 80821, (Mouse) 114874
phospholipase activity
metal ion binding
molecular_function
prenylcysteine methylesterase activity
lipase activity
hydrolase activity
1-oxa-2-oxocycloheptane lactonase activity
sulfolactone hydrolase activity
3,4-dihydrocoumarin hydrolase activity
butyrolactone hydrolase activity
endosulfan lactone lactonase activity
L-ascorbate 6-phosphate lactonase activity
Ser-tRNA(Thr) hydrolase activity
Ala-tRNA(Pro) hydrolase activity
Cys-tRNA(Pro) hydrolase activity
Ser(Gly)-tRNA(Ala) hydrolase activity
all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
retinyl-palmitate esterase activity
mannosyl-oligosaccharide 1,6-alpha-mannosidase activity
mannosyl-oligosaccharide 1,3-alpha-mannosidase activity
methyl indole-3-acetate esterase activity
methyl salicylate esterase activity
methyl jasmonate esterase activity
hydrolase
lipase
phospholipase
metabolite interconversion enzyme
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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