This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
A suggested positive control is human kidney tissue lysate.
PA5-20495 can be used with blocking peptide PEP-0615.
RTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.
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Protein Aliases: Dexamethasone-induced gene 2 protein; Dig2, REDD-1, REDD1, RP11-442H21.1, RTP801; DNA damage-inducible transcript 4 protein; DNA-damage-inducible transcript 4; DNA-damage-inducible transcript 4 protein; HIF-1 responsive protein RTP801; HIF-1 responsive RTP801; HIF-1 responsive RTP801 (RTP801); Protein regulated in development and DNA damage response 1; REDD-1
Gene Aliases: 5830413E08Rik; AA415483; DDIT4; Dig2; REDD-1; REDD1; RTP801