This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation end products (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.
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Protein Aliases: advanced glycation end-product receptor 1; advanced glycation endproduct receptor 1; AGE-R1; DDOST 48 kDa subunit; dolichyl-di-phosphooligosaccharide-protein glycotransferase; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic); dolichyl-diphosphooligosaccharide-protein glycotransferase; MGC2191; oligosaccharyl transferase 48 kDa subunit; oligosaccharyltransferase 48 kDa subunit; oligosaccharyltransferase subunit 48
Gene Aliases: AGER1; CDG1R; DDOST; KIAA0115; OK/SW-cl.45; OKSWcl45; OST; OST48; WBP1
Molecular Function: glycosyltransferase