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DDX11 Polyclonal Antibody
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Product Details
BS-7719R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human DDX11, amino acids 231-330.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX11 encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. DDX11 is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genomestability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent DNA helicase DDX11; CHL1-like helicase homolog; CHL1-related helicase gene-1; CHL1-related protein 1; DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae); DEAD/H box protein 11; DEAD/H-box protein 11; DNA 5'-3' helicase DDX11; hCHLR1; Keratinocyte growth factor-regulated gene 2 protein; KRG-2; probable ATP-dependent DNA helicase DDX11; probable ATP-dependent RNA helicase DDX11; unnamed protein product
Gene Aliases: CHL1; CHLR1; DDX11; KRG2; WABS
UniProt ID: (Human) Q96FC9
Entrez Gene ID: (Human) 1663
nucleotide binding
nucleic acid binding
DNA binding
DNA helicase activity
chromatin binding
DNA replication origin binding
double-stranded DNA binding
single-stranded DNA binding
RNA binding
single-stranded RNA binding
helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
RNA-dependent ATPase activity
hydrolase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
isomerase activity
ATPase activity
5'-3' DNA helicase activity
triplex DNA binding
metal ion binding
iron-sulfur cluster binding
4 iron, 4 sulfur cluster binding
G-quadruplex DNA binding
catalytic activity, acting on a nucleic acid
nucleobase-containing compound metabolic process
DNA replication
DNA repair
cellular response to DNA damage stimulus
sister chromatid cohesion
replication fork processing
negative regulation of protein binding
establishment of sister chromatid cohesion
positive regulation of chromatin binding
positive regulation of sister chromatid cohesion
cellular response to hydroxyurea
cellular response to cisplatin
positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
cellular response to bleomycin
nucleolar chromatin organization
positive regulation of double-strand break repair
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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