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Invitrogen
DDX5 Polyclonal Antibody
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Product Details
PA5-17042
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues surrounding Gly487 of human DDX5
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent RNA helicase DDX5; D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 5; ddx5 gene protein; DEAD (Asp-Glu-Ala-Asp) box helicase 5; DEAD (Asp-Glu-Ala-Asp) box polypeptide 5; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 5; DEAD box protein 5; DEAD box RNA helicase DEAD1; DEAD box-5; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD); DKFZp434E109; DKFZp686J01190; mDEAD1; MGC118083; p68 RNA helicase; Probable ATP-dependent RNA helicase DDX5; RNA helicase p68; RP23-247J12.4; unnamed protein product
Gene Aliases: 2600009A06Rik; DDX5; G17P1; HELR; HLR1; HUMP68; p68
UniProt ID: (Human) P17844
Entrez Gene ID: (Human) 1655, (Mouse) 13207, (Rat) 287765
nucleotide binding
nucleic acid binding
RNA binding
RNA helicase activity
mRNA binding
mRNA 3'-UTR binding
helicase activity
protein binding
calmodulin binding
ATP binding
hydrolase activity
ATPase activity
enzyme binding
MH2 domain binding
pre-mRNA binding
ribonucleoprotein complex binding
SMAD binding
calcium-dependent protein binding
androgen receptor binding
R-SMAD binding
primary miRNA binding
promoter-specific chromatin binding
transcription cofactor activity
transcription coactivator activity
ATP-dependent RNA helicase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
estrogen receptor binding
poly(A) RNA binding
negative regulation of transcription from RNA polymerase II promoter
alternative mRNA splicing, via spliceosome
regulation of alternative mRNA splicing, via spliceosome
mRNA splicing, via spliceosome
nuclear-transcribed mRNA catabolic process
epithelial to mesenchymal transition
regulation of transcription from RNA polymerase II promoter
mRNA processing
RNA splicing
mRNA transcription
BMP signaling pathway
intracellular estrogen receptor signaling pathway
androgen receptor signaling pathway
primary miRNA processing
positive regulation of DNA damage response, signal transduction by p53 class mediator
regulation of viral genome replication
myoblast differentiation
regulation of osteoblast differentiation
rhythmic process
regulation of androgen receptor signaling pathway
pri-miRNA transcription from RNA polymerase II promoter
intrinsic apoptotic signaling pathway by p53 class mediator
regulation of miRNA transcription
regulation of skeletal muscle cell differentiation
in utero embryonic development
transcription, DNA-templated
regulation of transcription, DNA-templated
circadian rhythm
RNA secondary structure unwinding
positive regulation of intracellular estrogen receptor signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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