Immunogen sequence: LSSNAVSQIT RMCLLKGNMG VCFDVPTTES ERLQAEWHDS DWILSVPAKL PEIEEYYDGN TSSNSRQRSG WSSG
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 95%.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX50 is a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. DDX50 and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. DDX50 gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined.
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Protein Aliases: ATP-dependent RNA helicase DDX50; DEAD (Asp-Glu-Ala-Asp) box polypeptide 50; DEAD box protein 50; Gu-beta; malignant cell derived RNA helicase; Nucleolar protein Gu2; RNA helicase II/Gu beta
Gene Aliases: DDX50; GU2; GUB; mcdrh; RH-II/GuB
UniProt ID: (Human) Q9BQ39
Entrez Gene ID: (Human) 79009