Immunogen sequence: TAYSLVAPDEI PYLLDLHLFL GRSLTLARPL KEPSGVAGVD GMLGRVPQSV VDEEDSGLQS TLEASLELRG LARVADNAQQ QYV
Highest antigen sequence identity to the following orthologs - mouse 76%, rat 78%.
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Protein Aliases: ATP-dependent RNA helicase DDX54; ATP-dependent RNA helicase DP97; DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; DEAD box helicase 97 KDa; DEAD box protein 54; DEAD box RNA helicase 97 kDa; DP97; MGC2835
Gene Aliases: DDX54; DP97
UniProt ID: (Human) Q8TDD1
Entrez Gene ID: (Human) 79039