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DECR2 Antibody (PA5-120571) in WB
Western blot analysis of DECR2 in extracts of various cell lines. Samples were incubated with DECR2 Polyclonal antibody (Product # PA5-120571) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3s.
Product Details
PA5-120571
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 140-240 of human DECR2 (NP_065715.1).
Conjugate
Form
Liquid
Concentration
1.48 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2914143
Product Specific Information
Positive test controls include: HeLa, Mouse liver, Rat liver, Rat kidney.
Immunogen sequence: GTFNVSRVLY EKFFRDHGGV IVNITATLGN RGQALQVHAG SAKAAVDAMT RHLAVEWGPQ NIRVNSLAPG PISGTEGLRR LGGPQASLST KVTASPLQRL G
Target Information
DECR2 (2, 4-dienoyl-CoA reductase 2), also known as PDCR (peroxisomal 2, 4-dienoyl-CoA reductase) or SDR17C1, is a 292 amino acid member of the short-chain dehydrogenases/reductases (SDR) protein family and the 2, 4-dienoyl-CoA reductase protein subfamily. Localized to the peroxisome, DECR2 is an auxiliary enzyme of beta-oxidation that catalyzes the NADP-dependent reduction of 2, 4-dienoyl-CoA to yield trans-3-enoyl-CoA. DECR2 has also been shown to have catalytic activity towards 2, 4, 7, 10, 13, 16, 19-docosaheptaenoyl-CoA and short and medium chain 2, 4-dienoyl-CoAs, suggesting that DECR2 is not a rate limiting step in the degradation of docosahexaenoic acid in the peroxisome. DECR2 is expressed as three isoforms produced by alternative splicing events.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2,4-dienoyl CoA reductase 2, peroxisomal; 2,4-dienoyl-CoA reductase 2; 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal; DCR-AKL; pDCR; peroxisomal 2,4-dienoyl-CoA reductase; Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]; putative peroxisomal 2,4-dienoyl-CoA reductase; putative peroxisomal 24-dienoyl-CoA reductase; pVI-AKL; Short chain dehydrogenase/reductase family 17C member 1; short chain dehydrogenase/reductase family 17C, member 1
Gene Aliases: Dcrakl; DECR2; PDCR; putativeperoxisomal24-dienoyl-CoAreductase; SDR17C1
UniProt ID: (Human) Q9NUI1, (Mouse) Q9WV68, (Rat) Q9Z2M4
Entrez Gene ID: (Human) 26063, (Mouse) 26378, (Rat) 64461
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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