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Invitrogen
DEDD2 Polyclonal Antibody
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Product Details
PA5-20214
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A peptide corresponding to 11 amino acids near the amino-terminus of human DEDD2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is RAW264.7 cell lysate.
PA5-20214 can be used with blocking peptide PEP-0311.
Target Information
Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: death effector domain containing 2; death effector domain-containing DNA-binding protein 2; DED-containing protein FLAME-3; DEDD2; DNA-binding death effector domain-containing protein 2; FADD-like anti-apoptotic molecule 3; unnamed protein product
Gene Aliases: 2410050E11Rik; DEDD2; FLAME-3; FLAME3; PSEC0004
UniProt ID: (Human) Q8WXF8, (Mouse) Q8QZV0
Entrez Gene ID: (Human) 162989, (Mouse) 67379, (Rat) 687118
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
extrinsic apoptotic signaling pathway via death domain receptors
apoptotic nuclear changes
regulation of apoptotic process
positive regulation of extrinsic apoptotic signaling pathway
RNA processing
rRNA catabolic process
cellular homeostasis
intracellular signal transduction
negative regulation of transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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