This antibody (25658-1-AP) can recognize all isoforms at 112 kDa and 52-64 kDa.
Clathrin-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2). Thus, connecdenns link RAB35 activation with the clathrin machinery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Connecdenn; Connecdenn 1; DENN domain-containing protein 1A; DENN/MADD domain containing 1A; Protein FAM31A; RP11-230L22.3
Gene Aliases: DENND1A; FAM31A; KIAA1608
UniProt ID: (Human) Q8TEH3
Entrez Gene ID: (Human) 57706