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Product Details
PA5-63150
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DEPDC5. Recombinant protein control fragment (Product #RP-95351).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2640530
Product Specific Information
Immunogen sequence: YDAQVFRLPG PSRAQCLTTC RSVRERESHS RKSASSCDVS SSPSLPSRTL PTEEVRSQAS DDSSLGKSAN ILMIPHPHLH QYEVSSS
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 91%.
Target Information
This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DEP domain-containing protein 5; DEPD5; GATOR1 complex protein DEPDC5
Gene Aliases: DEP.5; DEPDC5; FFEVF; KIAA0645
UniProt ID: (Human) O75140
Entrez Gene ID: (Human) 9681
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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