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Invitrogen
DERL1 Polyclonal Antibody
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Product Details
PA5-53444
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DERL1. Recombinant protein control fragment (Product #RP-91209).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LMFRYPMDLG GRNFLSTPQF LYRWLPSRRG GVSGFGVPPA SMRRAADQNG GGGRHNWGQG FRLGDQ
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Degradation in endoplasmic reticulum protein 1; Der1-like domain family, member 1; Der1-like protein 1; Derlin-1; DERtrin-1; predicted protein of HQ2577; unnamed protein product
Gene Aliases: DER-1; DER1; DERL1; derlin-1; UNQ243/PRO276
UniProt ID: (Human) Q9BUN8
Entrez Gene ID: (Human) 79139
response to unfolded protein
proteasomal protein catabolic process
protein transport
endoplasmic reticulum unfolded protein response
retrograde protein transport, ER to cytosol
positive regulation of protein ubiquitination
protein destabilization
cellular response to stress
cellular response to unfolded protein
ERAD pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
establishment of protein localization
cellular response to misfolded protein
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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