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Invitrogen
DFNB31 Polyclonal Antibody
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FIGURE: 1 / 1
DFNB31 Antibody (PA5-116523) in WB
Western blot analysis of DFNB31 in extracts of various cell lines. Samples were incubated with DFNB31 Polyclonal antibody (Product # PA5-116523) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-116523
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 708-907 of human WHRN (NP_0562193)
Conjugate
Form
Liquid
Concentration
0.92 mg/mL
Amount
92 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: U-87MG, HeLa, K-562, Mouse liver
Immunogen sequence: PSGHPDQTGT NQHFVMVEVH RPDSEPDVNE VRALPQTRTA STLSQLSDSG QTLSEDSGVD AGEAEASAPG RGRQSVSTKS RSSKELPRNE RPTDGANKPP GLLEPTSTLV RVKKSAATLG IAIEGGANTR QPLPRIVTIQ RGGSAHNCGQ LKVGHVILEV NGLTLRGKEH REAARIIAEA FKTKDRDYID FLVTEFNVML
Target Information
This gene is thought to function in the organization and stabilization of sterocilia elongation and actin cystoskeletal assembly, based on studies of the related mouse gene. Mutations in this gene have been associated with autosomal recessive non-syndromic deafness and Usher Syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Autosomal recessive deafness type 31 protein; CASK-interacting protein CIP98; unnamed protein product; whirler; Whirlin
Gene Aliases: 1110035G07Rik; AW122018; AW742671; C430046P22Rik; CIP98; DFNB31; KIAA1526; PDZD7B; USH2D; WHRN; WI
UniProt ID: (Human) Q9P202, (Mouse) Q80VW5
Entrez Gene ID: (Human) 25861, (Mouse) 73750
retina homeostasis
sensory perception of sound
positive regulation of gene expression
cerebellar Purkinje cell layer formation
establishment of protein localization
detection of mechanical stimulus involved in sensory perception of sound
sensory perception of light stimulus
establishment of localization in cell
auditory receptor cell stereocilium organization
inner ear receptor cell differentiation
inner ear receptor stereocilium organization
paranodal junction maintenance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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