This antibody is not applicable for IHC-paraffin embedded sections.
Suggested positive control: HepG2 lysate.
Glucose and insulin are anabolic signals which upregulate the transcriptions of a series of lipogenic enzymes to convert excess carbohydrate into triglycerides for efficient energy storage. DGAT1 is a microsomal enzyme that assists in the synthesis of fatty acids into triglycerides. DGAT catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol (DAG) and fatty acyl CoA as substrates. DGAT plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism such as intestinal fat absorption, lipoprotein assembly, adipose tissue formation, and lactation. DGAT1 is involved in fat absorption in the intestine and in basal level triglyceride synthesis in adipose tissue, where it is more highly expressed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ACAT related gene product 1; ACAT-related gene product 1; ACT-related gene product 1; Acyl coenzyme A; acyl coenzyme A:cholesterol acyltransferase related gene 1; Acyl-CoA retinol O-fatty-acyltransferase; acyl-CoA:diacylglycerol acyltransferase; acyl-coenzyme A:diacylglycerol acyltransferase 1; ARAT; DGAT1B; diacylglycerol acyltransferase; diacylglycerol acyltransferase 1; Diacylglycerol O-acyltransferase 1; diacylglycerol O-acyltransferase homolog 1; diacylglycerol O-acyltransferase homolog 1a; Diglyceride acyltransferase; EC 220.127.116.11; retinol O-fatty-acyltransferase
Gene Aliases: AGRP1; ARAT; ARGP1; BOS_13640; C75990; D15Ertd23e; DGAT; DGAT1; DIAR7; wu:fd36g11; zgc:77691