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Invitrogen
DGKD Polyclonal Antibody
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Product Details
PA5-45784
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the C-terminal of human DGKD (aa 1110-1159).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: KRSRSGKFRL VTKFKKEKNN KNKEAHSSLG APVHLWGTEE VAAWLEHLSL
Sequence homology: Dog: 79%; Guinea Pig: 93%; Human: 100%; Mouse: 92%; Rabbit: 86%; Rat: 100%
Target Information
Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DAG) to produce phosphatidic acid. DAG and phosphatidic acid are lipids that act as second messengers in signaling cascades. DGK-alpha influences cell activation and secretion of lethal exosomes, which in turn control cell death. DGK-beta is abundant in restricted brain regions such as the caudate putamen and olfactory tubercle. DGK-gamma encodes full-length and truncated transcripts that are present in a range of human tissues, with greatest expression observed in retina. DGK-delta is most abundant in skeletal muscle. DGK-epsilon shows specificity for arachidonylcontaining diacylglycerol and is expressed predominantly in testis. DGK-theta is most abundant in the cerebellum and hippocampus. DGK-iota is present in brain and retina as a predominant transcript of more than 12 kb, including a long 3-prime untranslated region, with additional low abundance transcripts of 9.5 and 7.5 kb. DGK-eta is closely related to DGK-delta. DGK-zeta is most abundant in brain and muscle. DGKs have structural motifs that play regulatory roles, and these motifs form the basis for dividing the DGKs into five subtypes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 130 kDa diacylglycerol kinase; DAG kinase delta; DGK delta; DGK-delta; Diacylglycerol kinase delta; diacylglycerol kinase, delta 130kDa; Diglyceride kinase; Diglyceride kinase delta; EC 2.7.1.107; FLJ26930; unnamed protein product
Gene Aliases: DGK-delta; DGKD; dgkd-2; DGKdelta; KIAA0145
UniProt ID: (Human) Q16760
Entrez Gene ID: (Human) 8527
lipid metabolic process
phosphatidic acid biosynthetic process
endocytosis
signal transduction
phospholipase C-activating G-protein coupled receptor signaling pathway
protein transport
platelet activation
intracellular signal transduction
positive regulation of epidermal growth factor receptor signaling pathway
diacylglycerol metabolic process
diacylglycerol catabolic process
phosphatidic acid metabolic process
glycerolipid metabolic process
lipid phosphorylation
negative regulation of phospholipase C/protein kinase C signal transduction
positive regulation of clathrin-mediated endocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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