Peptide sequence: KRSRSGKFRL VTKFKKEKNN KNKEAHSSLG APVHLWGTEE VAAWLEHLSL
Sequence homology: Dog: 79%; Guinea Pig: 93%; Human: 100%; Mouse: 92%; Rabbit: 86%; Rat: 100%
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.
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Protein Aliases: 130 kDa diacylglycerol kinase; DAG kinase delta; DGK-delta; dgkd-2; DGKdelta; diacylglycerol kinase; Diacylglycerol kinase delta; diacylglycerol kinase, delta; diacylglycerol kinase, delta 130kDa; Diglyceride kinase delta; FLJ26930; KIAA0145
Gene Aliases: AI841987; D330025K09; DGKD; dgkd-2; DGKdelta; KIAA0145; RGD1563309
UniProt ID: (Human) Q16760