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Proteintech
DGKE Polyclonal Antibody
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Product Details
11900-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DGKE Fusion Protein Ag2512 (1-177 aa encoded by BC022297)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEAERRPAP GSPSEGLFAD GHLILWTLCS VLLPVFITFW CSLQRSRRQL HRRDIFRKSK HGWRDTDLFS QPTYCCVCAQ HILQGAFCDC CGLRVDEGCL RKADKRFQCK EIMLKNDTKV LDAMPHHWIR GNVPLCSYCM VCKQQCGCQP KLCDYRYGLR GHSLSQNAPW ESGFHRVV (1-177 aa encoded by BC022297)
Target Information
Diacylglycerol (DAG) influences numerous cell signaling cascades by functioning as an intracellular, allosteric activator of protein kinase C (PKC), and as a potent activator of guanine nucleotide exchange factors. In order to maintain cellular homeostasis, intracellular DAG levels are tightly regulated by diacylglycerol kinases (DGKs, DAGKs), which phosphorylate DAG to phosphatidic acid, thus removing DAG. Human DGK-alpha (80 kDa), -beta (90 kDa), and - gamma (90 kDa) have calcium-binding EF-hand motifs at their N termini and are classified as type I DGKs. Human DGK- delta (130 kDa) and DGK-i (130 kDa) contain N-terminal pleckstrin homology (PH) domains and are classified as type II. Human DGK- epsilon (64 kDa) contains no identifiable regulatory domains and is classified as a type III DGK. Human DGK- zeta (104 kDa) and -iota (130 kDa) possess C-terminal ankyrin repeats and are classified as type IV DGKs. Human DGK-theta (110 kDa) contains 3 cysteine-rich domains and a PH domain and is classified as a type V DGK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DAG kinase epsilon; DGK-epsilon; Diacylglycerol kinase epsilon; diacylglycerol kinase, epsilon 64kDa; Diglyceride kinase epsilon; EC 2.7.1.107; unnamed protein product
Gene Aliases: AHUS7; C87606; DAGK5; DAGK6; DGK; DGKE; NPHS7
UniProt ID: (Human) P52429, (Mouse) Q9R1C6
Entrez Gene ID: (Human) 8526, (Mouse) 56077, (Rat) 497978
lipid metabolic process
phosphatidic acid biosynthetic process
phosphatidylinositol biosynthetic process
signal transduction
phospholipase C-activating G-protein coupled receptor signaling pathway
platelet activation
intracellular signal transduction
diacylglycerol metabolic process
glycerophospholipid biosynthetic process
glycerolipid metabolic process
lipid phosphorylation
modulation of synaptic transmission
protein kinase C-activating G-protein coupled receptor signaling pathway
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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