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Proteintech
DGKQ Polyclonal Antibody
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Product Details
17885-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DGKQ Fusion Protein Ag11938 (595-942 aa encoded by BC063801)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
37.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PKSGGLKGR DLLCSFRKLL NPHQVFDLTN GGPLPGLHLF SQVPCFRVLV CGGDGTVGWV LGALEETRYR LACPEPSVAI LPLGTGNDLG RVLRWGAGYS GEDPFSVLLS VDEADAVLMD RWTILLDAHE AGSAENDTAD AEPPKIVQMS NYCGIGIDAE LSLDFHQARE EEPGKFTSRL HNKGVYVRVG LQKISHSRSL HKQIRLQVER QEVELPSIEG LIFINIPSWG SGADLWGSDS DTRFEKPRMD DGLLEVVGVT GVVHMGQVQG GLRSGIRIAQ GSYFRVTLLK ATPVQVDGEP WVQAPGHMII SAAGPKVHML RKAKQKPRRA GTTRDARADA APAPESDPR (595-942 aa encoded by BC063801)
Target Information
Diacylglycerol (DAG) is a fundamental lipid second messenger that is produced in the nucleus. The accumulation of DAG in the nucleus is important for the regulation of cell growth and differentiation. Diacylglycerol kinases (DGKs) convert DAG to phosphatidic acid, thereby terminating diacylglycerol signaling, which results in the reduction of protein kinase C activity and cell cycle progression of T lymphocytes. Diacylglycerol kinases are divided into five subtypes, Type I-Type V. DGK-theta is a Type V DGK, and localizes mainly to the nucleus of various cell lines, such as MDA-MB-453, MCF-7, PC12 and HeLa. Nuclear DGK-theta co-localizes with phosphatidylinositol 4, 5-bisphosphate (PIP(2)). DGK-theta is the isoform responsive to alpha-Thrombin stimulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DAG kinase theta; Dgk theta; DGK-theta; DGKtheta; Diacylglycerol kinase theta; diacylglycerol kinase, delta (110 kDa); diacylglycerol kinase, theta 110kDa; Diglyceride kinase theta; testis tissue sperm-binding protein Li 38a
Gene Aliases: 110kDa; DAGK; DAGK4; DAGK7; Dgkd; DGKQ
UniProt ID: (Human) P52824, (Rat) D3ZEY4, (Mouse) Q6P5E8
Entrez Gene ID: (Human) 1609, (Rat) 100361138, (Mouse) 110524
nucleotide binding
diacylglycerol kinase activity
protein kinase C activity
protein binding
ATP binding
zinc ion binding
kinase activity
transferase activity
kinase binding
transmembrane receptor protein tyrosine kinase activator activity
receptor tyrosine kinase binding
phospholipase binding
metal ion binding
alkylglycerol kinase activity
DNA-binding transcription factor binding
NAD+ kinase activity
activating transcription factor binding
kinase
regulation of gluconeogenesis
regulation of transcription from RNA polymerase II promoter
lipid metabolic process
phosphatidic acid biosynthetic process
signal transduction
epidermal growth factor receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of gene expression
negative regulation of gene expression
platelet activation
intracellular signal transduction
diacylglycerol metabolic process
glycerolipid metabolic process
lipid phosphorylation
response to cAMP
thrombin receptor signaling pathway
positive regulation of protein kinase C signaling
regulation of cholesterol metabolic process
regulation of synaptic vesicle endocytosis
cellular response to bile acid
regulation of TORC1 signaling
regulation of cortisol biosynthetic process
regulation of progesterone biosynthetic process
protein kinase C-activating G-protein coupled receptor signaling pathway
phosphorylation
cAMP-mediated signaling
response to ATP
protein kinase C signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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