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Product Details
PA5-92446
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 227-516 of human DHCR24 |
Conjugate |
Unconjugated |
Form |
liquid |
Concentration |
0.42 mg/mL |
Purification |
Affinity Chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2806505 |
Product Specific Information
Immunogen sequence: AEIRIIPAKK YVKLRFEPVR GLEAICAKFT HESQRQENHF VEGLLYSLDE AVIMTGVMTD EAEPSKLNSI GNYYKPWFFK HVENYLKTNR EGLEYIPLRH YYHRHTRSIF WELQDIIPFG NNPIFRYLFG WMVPPKISLL KLTQGETLRK LYEQHHVVQD MLVPMKCLQQ ALHTFQNDIH VYPIWLCPFI LPSQPGLVHP KGNEAELYID IGAYGEPRVK HFEARSCMRQ LEKFVRSVHG FQMLYADCYM NREEFWEMFD GSLYHKLREK LGCQDAFPEV YDKICKAARH; Positive Samples: U-87MG, HT-29, PC-12, NCI-H460; Cellular Location: Endoplasmic reticulum membrane, Golgi apparatus membrane, Single-pass membrane protein
Target Information
DHCR24 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. This protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of its gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 24-dehydrocholesterol reductase; 3 beta-hydroxysterol delta 24-reductase; 3-beta-hydroxysterol delta-24 reductase; 3-beta-hydroxysterol Delta-24-reductase; Delta(24)-sterol reductase; desmosterol-to-cholesterol enzyme; Diminuto/dwarf1 homolog; seladin 1; Seladin-1; selective AD indicator 1
Gene Aliases: 2310076D10Rik; 5830417J06Rik; DCE; DHCR24; KIAA0018; mKIAA0018; Nbla03646; seladin-1; SELADIN1
UniProt ID: (Human) Q15392, (Mouse) Q8VCH6
Entrez Gene ID: (Human) 1718, (Rat) 298298, (Mouse) 74754
Molecular Function:
reductase
cholesterol biosynthetic process
apoptotic process
response to oxidative stress
cell cycle arrest
Ras protein signal transduction
protein localization
negative regulation of cell proliferation
response to hormone
tissue development
male genitalia development
plasminogen activation
cholesterol biosynthetic process via desmosterol
cholesterol biosynthetic process via lathosterol
amyloid precursor protein catabolic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
skin development
oxidation-reduction process
membrane organization
regulation of neuron death
steroid metabolic process
cholesterol metabolic process
sterol metabolic process
lipid metabolic process
steroid biosynthetic process
sterol biosynthetic process
delta24(24-1) sterol reductase activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
enzyme binding
peptide antigen binding
delta24-sterol reductase activity
flavin adenine dinucleotide binding
UDP-N-acetylmuramate dehydrogenase activity
oxidoreductase activity
catalytic activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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