Product References
Depletion of SOD2 enhances nasopharyngeal carcinoma cell radiosensitivity via ferroptosis induction modulated by DHODH inhibition.
BMC cancer
Amos A,Jiang N,Zong D,Gu J,Zhou J,Yin L,He X,Xu Y,Wu L
Fri Feb 03 00:00:00 UTC 2023
Glucose Starvation Inhibits Ferroptosis by Activating the LKB1/AMPK Signaling Pathway and Promotes the High Speed Linear Motility of Dairy Goat Sperm.
Animals : an open access journal from MDPI
Li Y,Zhang G,Wen F,Xian M,Guo S,Zhang X,Feng X,Hu Z,Hu J
Sun Apr 23 00:00:00 UTC 2023
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.
Cell research
Qiu S,Zhong X,Meng X,Li S,Qian X,Lu H,Cai J,Zhang Y,Wang M,Ye Z,Zhang H,Gao P
Sat Apr 01 00:00:00 UTC 2023
ML390 inhibits enterovirus 71 replication by targeting de novo pyrimidine biosynthesis pathway.
Antiviral research
Yang Q,Wu C,Zhu G,Ren F,Lin B,Huang R,Hu X,Zhao D,Peng K,Wu Y,Wang Q,Huang C,Zhang D
Sun Jan 01 00:00:00 UTC 2023
Neurotoxic A1 astrocytes promote neuronal ferroptosis via CXCL10/CXCR3 axis in epilepsy.
Free radical biology & medicine
Liang P,Zhang X,Zhang Y,Wu Y,Song Y,Wang X,Chen T,Liu W,Peng B,Yin J,He F,Fan Y,Han S,He X
Wed Feb 01 00:00:00 UTC 2023
SLC25A22 as a Key Mitochondrial Transporter Against Ferroptosis by Producing Glutathione and Monounsaturated Fatty Acids.
Antioxidants & redox signaling
Liu Y,Wang Y,Lin Z,Kang R,Tang D,Liu J
Sat Jul 01 00:00:00 UTC 2023
Dihydroorotate dehydrogenase regulates ferroptosis in neurons after spinal cord injury via the P53-ALOX15 signaling pathway.
CNS neuroscience & therapeutics
Li D,Lu X,Xu G,Liu S,Gong Z,Lu F,Xia X,Jiang J,Wang H,Zou F,Ma X
Sat Jul 01 00:00:00 UTC 2023
SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
Cell death & disease
Cheng L,He Q,Liu B,Chen L,Lv F,Li X,Li Y,Liu C,Song Y,Xing Y
Tue Jan 31 00:00:00 UTC 2023
SIRT6 drives sensitivity to ferroptosis in anaplastic thyroid cancer through NCOA4-dependent autophagy.
American journal of cancer research
Yang Z,Huang R,Wang Y,Guan Q,Li D,Wu Y,Liao T,Wang Y,Xiang J
Sat Mar 11 00:00:00 UTC 2023
Tryptophan Metabolism Acts as a New Anti-Ferroptotic Pathway to Mediate Tumor Growth.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu D,Liang CH,Huang B,Zhuang X,Cui W,Yang L,Yang Y,Zhang Y,Fu X,Zhang X,Du L,Gu W,Wang X,Yin C,Chai R,Chu B
Wed Feb 01 00:00:00 UTC 2023
3,3'-Diindolylmethane Enhances Fluorouracil Sensitivity via Inhibition of Pyrimidine Metabolism in Colorectal Cancer.
Metabolites
Zhang J,Zou S,Zhang Y,Yang Z,Wang W,Meng M,Feng J,Zhang P,Xiao L,Lee MH,Fang L
Sat Apr 30 00:00:00 UTC 2022
Designer Exosomes for Targeted Delivery of a Novel Therapeutic Cargo to Enhance Sorafenib-Mediated Ferroptosis in Hepatocellular Carcinoma.
Frontiers in oncology
Li X,Yu Q,Zhao R,Guo X,Liu C,Zhang K,Zhang W,Liu J,Yu J,Wang S,Hao Q,Li W,Zhang W,Li M,Zhang Y,Zhang C,Gao Y
Sat Jul 16 00:00:00 UTC 2022
Designer Exosomes for Targeted Delivery of a Novel Therapeutic Cargo to Enhance Sorafenib-Mediated Ferroptosis in Hepatocellular Carcinoma.
Frontiers in oncology
Li X,Yu Q,Zhao R,Guo X,Liu C,Zhang K,Zhang W,Liu J,Yu J,Wang S,Hao Q,Li W,Zhang W,Li M,Zhang Y,Zhang C,Gao Y
Sat Jul 16 00:00:00 UTC 2022
Designer Exosomes for Targeted Delivery of a Novel Therapeutic Cargo to Enhance Sorafenib-Mediated Ferroptosis in Hepatocellular Carcinoma.
Frontiers in oncology
Li X,Yu Q,Zhao R,Guo X,Liu C,Zhang K,Zhang W,Liu J,Yu J,Wang S,Hao Q,Li W,Zhang W,Li M,Zhang Y,Zhang C,Gao Y
Sat Jul 16 00:00:00 UTC 2022
Designer Exosomes for Targeted Delivery of a Novel Therapeutic Cargo to Enhance Sorafenib-Mediated Ferroptosis in Hepatocellular Carcinoma.
Frontiers in oncology
Li X,Yu Q,Zhao R,Guo X,Liu C,Zhang K,Zhang W,Liu J,Yu J,Wang S,Hao Q,Li W,Zhang W,Li M,Zhang Y,Zhang C,Gao Y
Sat Jul 16 00:00:00 UTC 2022
Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Li B,Chen X,Qiu W,Zhao R,Duan J,Zhang S,Pan Z,Zhao S,Guo Q,Qi Y,Wang W,Deng L,Ni S,Sang Y,Xue H,Liu H,Li G
Wed Jun 01 00:00:00 UTC 2022
Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Li B,Chen X,Qiu W,Zhao R,Duan J,Zhang S,Pan Z,Zhao S,Guo Q,Qi Y,Wang W,Deng L,Ni S,Sang Y,Xue H,Liu H,Li G
Wed Jun 01 00:00:00 UTC 2022
Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Li B,Chen X,Qiu W,Zhao R,Duan J,Zhang S,Pan Z,Zhao S,Guo Q,Qi Y,Wang W,Deng L,Ni S,Sang Y,Xue H,Liu H,Li G
Wed Jun 01 00:00:00 UTC 2022
Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Li B,Chen X,Qiu W,Zhao R,Duan J,Zhang S,Pan Z,Zhao S,Guo Q,Qi Y,Wang W,Deng L,Ni S,Sang Y,Xue H,Liu H,Li G
Wed Jun 01 00:00:00 UTC 2022
RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m6A-dependent manner.
Cell death & disease
Sun S,Gao T,Pang B,Su X,Guo C,Zhang R,Pang Q
Fri Jan 21 00:00:00 UTC 2022
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma.
Cancer cell
Pal S,Kaplan JP,Nguyen H,Stopka SA,Savani MR,Regan MS,Nguyen QD,Jones KL,Moreau LA,Peng J,Dipiazza MG,Perciaccante AJ,Zhu X,Hunsel BR,Liu KX,Alexandrescu S,Drissi R,Filbin MG,McBrayer SK,Agar NYR,Chowdhury D,Haas-Kogan DA
Mon Sep 12 00:00:00 UTC 2022
Isoliquiritigenin alleviates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Huang S,Wang Y,Xie S,Lai Y,Mo C,Zeng T,Kuang S,Zhou C,Zeng Z,Chen Y,Huang S,Gao L,Lv Z
Fri Jul 01 00:00:00 UTC 2022
A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers.
Nature communications
Koppula P,Lei G,Zhang Y,Yan Y,Mao C,Kondiparthi L,Shi J,Liu X,Horbath A,Das M,Li W,Poyurovsky MV,Olszewski K,Gan B
Fri Apr 22 00:00:00 UTC 2022
De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.
Cancer cell
Shi DD,Savani MR,Levitt MM,Wang AC,Endress JE,Bird CE,Buehler J,Stopka SA,Regan MS,Lin YF,Puliyappadamba VT,Gao W,Khanal J,Evans L,Lee JH,Guo L,Xiao Y,Xu M,Huang B,Jennings RB,Bonal DM,Martin-Sandoval MS,Dang T,Gattie LC,Cameron AB,Lee S,Asara JM,Kornblum HI,Mak TW,Looper RE,Nguyen QD,Signoretti S,Gradl S,Sutter A,Jeffers M,Janzer A,Lehrman MA,Zacharias LG,Mathews TP,Losman JA,Richardson TE,Cahill DP,DeBerardinis RJ,Ligon KL,Xu L,Ly P,Agar NYR,Abdullah KG,Harris IS,Kaelin WG,McBrayer SK
Mon Sep 12 00:00:00 UTC 2022
A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria.
Proceedings of the National Academy of Sciences of the United States of America
Wu S,Mao C,Kondiparthi L,Poyurovsky MV,Olszewski K,Gan B
Tue Jun 28 00:00:00 UTC 2022
Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma.
Cancer cell
Gwynne WD,Suk Y,Custers S,Mikolajewicz N,Chan JK,Zador Z,Chafe SC,Zhai K,Escudero L,Zhang C,Zaslaver O,Chokshi C,Shaikh MV,Bakhshinyan D,Burns I,Chaudhry I,Nachmani O,Mobilio D,Maich WT,Mero P,Brown KR,Quaile AT,Venugopal C,Moffat J,Montenegro-Burke JR,Singh SK
Mon Dec 12 00:00:00 UTC 2022
Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway.
Nature communications
Soflaee MH,Kesavan R,Sahu U,Tasdogan A,Villa E,Djabari Z,Cai F,Tran DH,Vu HS,Ali ES,Rion H,O'Hara BP,Kelekar S,Hallett JH,Martin M,Mathews TP,Gao P,Asara JM,Manning BD,Ben-Sahra I,Hoxhaj G
Mon May 16 00:00:00 UTC 2022
Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress.
Nature communications
Yang R,Yang C,Ma L,Zhao Y,Guo Z,Niu J,Chu Q,Ma Y,Li B
Thu Nov 17 00:00:00 UTC 2022
De novo pyrimidine synthesis fuels glycolysis and confers chemoresistance in gastric cancer.
Cancer letters
He D,Chen M,Chang L,Gu J,Liu F,Gao X,Ruan Y
Mon Nov 28 00:00:00 UTC 2022
Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure Through Inhibiting GSK3β-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis.
Cellular and molecular gastroenterology and hepatology
Huang S,Wang Y,Xie S,Lai Y,Mo C,Zeng T,Kuang S,Deng G,Zhou C,Chen Y,Huang S,Gao L,Lv Z
Thu May 19 00:00:00 UTC 2022
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer.
Nature
Mao C,Liu X,Zhang Y,Lei G,Yan Y,Lee H,Koppula P,Wu S,Zhuang L,Fang B,Poyurovsky MV,Olszewski K,Gan B
Sat May 01 00:00:00 UTC 2021
Genome-wide CRISPR screening reveals nucleotide synthesis negatively regulates autophagy.
The Journal of biological chemistry
Mimura K,Sakamaki JI,Morishita H,Kawazu M,Mano H,Mizushima N
Tue Aug 31 00:00:00 UTC 2021
Genome-wide CRISPR screening reveals nucleotide synthesis negatively regulates autophagy.
The Journal of biological chemistry
Mimura K,Sakamaki JI,Morishita H,Kawazu M,Mano H,Mizushima N
Tue Aug 31 00:00:00 UTC 2021
Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.
Cell metabolism
Halbrook CJ,Pontious C,Kovalenko I,Lapienyte L,Dreyer S,Lee HJ,Thurston G,Zhang Y,Lazarus J,Sajjakulnukit P,Hong HS,Kremer DM,Nelson BS,Kemp S,Zhang L,Chang D,Biankin A,Shi J,Frankel TL,Crawford HC,Morton JP,Pasca di Magliano M,Lyssiotis CA
Tue Jun 04 00:00:00 UTC 2019
Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.
Cell metabolism
Bajzikova M,Kovarova J,Coelho AR,Boukalova S,Oh S,Rohlenova K,Svec D,Hubackova S,Endaya B,Judasova K,Bezawork-Geleta A,Kluckova K,Chatre L,Zobalova R,Novakova A,Vanova K,Ezrova Z,Maghzal GJ,Magalhaes Novais S,Olsinova M,Krobova L,An YJ,Davidova E,Nahacka Z,Sobol M,Cunha-Oliveira T,Sandoval-Acuña C,Strnad H,Zhang T,Huynh T,Serafim TL,Hozak P,Sardao VA,Koopman WJH,Ricchetti M,Oliveira PJ,Kolar F,Kubista M,Truksa J,Dvorakova-Hortova K,Pacak K,Gurlich R,Stocker R,Zhou Y,Berridge MV,Park S,Dong L,Rohlena J,Neuzil J
Tue Feb 05 00:00:00 UTC 2019
Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.
Cell metabolism
Bajzikova M,Kovarova J,Coelho AR,Boukalova S,Oh S,Rohlenova K,Svec D,Hubackova S,Endaya B,Judasova K,Bezawork-Geleta A,Kluckova K,Chatre L,Zobalova R,Novakova A,Vanova K,Ezrova Z,Maghzal GJ,Magalhaes Novais S,Olsinova M,Krobova L,An YJ,Davidova E,Nahacka Z,Sobol M,Cunha-Oliveira T,Sandoval-Acuña C,Strnad H,Zhang T,Huynh T,Serafim TL,Hozak P,Sardao VA,Koopman WJH,Ricchetti M,Oliveira PJ,Kolar F,Kubista M,Truksa J,Dvorakova-Hortova K,Pacak K,Gurlich R,Stocker R,Zhou Y,Berridge MV,Park S,Dong L,Rohlena J,Neuzil J
Tue Feb 05 00:00:00 UTC 2019
Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties.
Molecular cancer therapeutics
Cao L,Weetall M,Trotta C,Cintron K,Ma J,Kim MJ,Furia B,Romfo C,Graci JD,Li W,Du J,Sheedy J,Hedrick J,Risher N,Yeh S,Qi H,Arasu T,Hwang S,Lennox W,Kong R,Petruska J,Moon YC,Babiak J,Davis TW,Jacobson A,Almstead NG,Branstrom A,Colacino JM,Peltz SW
Tue Jan 01 00:00:00 UTC 2019
Mitochondrial fusion exploits a therapeutic vulnerability of pancreatic cancer.
JCI insight
Yu M,Nguyen ND,Huang Y,Lin D,Fujimoto TN,Molkentine JM,Deorukhkar A,Kang Y,San Lucas FA,Fernandes CJ,Koay EJ,Gupta S,Ying H,Koong AC,Herman JM,Fleming JB,Maitra A,Taniguchi CM
Tue Jul 23 00:00:00 UTC 2019
Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia.
Nature communications
Wang Y,Bai C,Ruan Y,Liu M,Chu Q,Qiu L,Yang C,Li B
Mon Jan 14 00:00:00 UTC 2019
Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia.
Nature communications
Wang Y,Bai C,Ruan Y,Liu M,Chu Q,Qiu L,Yang C,Li B
Mon Jan 14 00:00:00 UTC 2019
Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells.
Haematologica
Wu D,Wang W,Chen W,Lian F,Lang L,Huang Y,Xu Y,Zhang N,Chen Y,Liu M,Nussinov R,Cheng F,Lu W,Huang J
Sat Sep 01 00:00:00 UTC 2018
Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells.
Haematologica
Wu D,Wang W,Chen W,Lian F,Lang L,Huang Y,Xu Y,Zhang N,Chen Y,Liu M,Nussinov R,Cheng F,Lu W,Huang J
Sat Sep 01 00:00:00 UTC 2018
Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis.
Nature communications
Santana-Codina N,Roeth AA,Zhang Y,Yang A,Mashadova O,Asara JM,Wang X,Bronson RT,Lyssiotis CA,Ying H,Kimmelman AC
Fri Nov 23 00:00:00 UTC 2018
Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis.
Nature communications
Santana-Codina N,Roeth AA,Zhang Y,Yang A,Mashadova O,Asara JM,Wang X,Bronson RT,Lyssiotis CA,Ying H,Kimmelman AC
Fri Nov 23 00:00:00 UTC 2018
PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition.
Cancer discovery
Mathur D,Stratikopoulos E,Ozturk S,Steinbach N,Pegno S,Schoenfeld S,Yong R,Murty VV,Asara JM,Cantley LC,Parsons R
Sat Apr 01 00:00:00 UTC 2017
The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels.
Cell reports
Hoxhaj G,Hughes-Hallett J,Timson RC,Ilagan E,Yuan M,Asara JM,Ben-Sahra I,Manning BD
Tue Oct 31 00:00:00 UTC 2017
The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels.
Cell reports
Hoxhaj G,Hughes-Hallett J,Timson RC,Ilagan E,Yuan M,Asara JM,Ben-Sahra I,Manning BD
Tue Oct 31 00:00:00 UTC 2017
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
Science (New York, N.Y.)
Ben-Sahra I,Howell JJ,Asara JM,Manning BD
Fri Mar 15 00:00:00 UTC 2013
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
Science (New York, N.Y.)
Ben-Sahra I,Howell JJ,Asara JM,Manning BD
Fri Mar 15 00:00:00 UTC 2013
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
Science (New York, N.Y.)
Ben-Sahra I,Howell JJ,Asara JM,Manning BD
Fri Mar 15 00:00:00 UTC 2013