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Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CR; dehydrogenase/reductase (SDR family) member 4 like 2A; Dehydrogenase/reductase SDR family member 4; NADPH-dependent carbonyl reductase; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase; NRDR; Peroxisomal short-chain alcohol dehydrogenase; PH PSCD; Protein SDR25C2; PSCD; SCAD-SRL; Short chain dehydrogenase/reductase family 25C member 2; short chain dehydrogenase/reductase family 25C, member 1; short chain dehydrogenase/reductase family 25C, member 2; Short-chain dehydrogenase/reductase family member 4
Gene Aliases: CR; DHRS4; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL; SDR25C1; SDR25C2; UNQ851/PRO1800
UniProt ID: (Human) D3YTB8
Entrez Gene ID: (Human) 10901
Molecular Function: dehydrogenase