The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
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Protein Aliases: 2-oxoadipate dehydrogenase complex component E1; 2-oxoadipate dehydrogenase, mitochondrial; Alpha-KADH-E1; Alpha-ketoadipate dehydrogenase; Dehydrogenase E1 and transketolase domain-containing protein 1; DKFZp762M115; E1a; MGC3090; Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
Gene Aliases: AMOXAD; CMT2Q; DHTKD1; KIAA1630
UniProt ID: (Human) Q96HY7
Entrez Gene ID: (Human) 55526
Molecular Function: dehydrogenase