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Invitrogen
DHX36 Polyclonal Antibody
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Product Details
PA5-100473
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DHX36(Accession Q9H2U1), corresponding to amino acid residues I942-K992.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total DHX36.
Target Information
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure. DHX36 (DEAH box protein 36), also known as MLE-like protein 1 and RNA helicase associated with AU-rich element ARE (RHAU), belongs to RNA helicase of the DEAH family and may function in sex development and spermatogenesis. It is expressed in testis and is evolutionary conserved with true orthologs in almost all animal species. DHX36 plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. DHX36 is required for early embryogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Asp-Glu-Ala-His; ATP-dependent DNA/RNA helicase DHX36; ATP-dependent RNA helicase DHX36; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36; DEAD/H box polypeptide 36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; DEAH box protein 36; DEAH-box protein 36; G4 resolvase-1; G4-resolvase 1; G4-resolvase-1; G4R1; MLE-like protein 1; probable ATP-dependent RNA helicase DHX36; RNA helicase associated with AU-rich element ARE; RNA helicase associated with AU-rich element protein
Gene Aliases: 2810407E23Rik; AI452301; AU022184; DDX36; DHX36; G4R1; KIAA1488; mKIAA1488; MLEL1; RHAU
UniProt ID: (Human) Q9H2U1, (Rat) D4A2Z8, (Mouse) Q8VHK9
Entrez Gene ID: (Human) 170506, (Rat) 310461, (Mouse) 72162
core promoter binding
G-quadruplex RNA binding
double-stranded RNA binding
ATP-dependent RNA helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
histone deacetylase binding
transcription regulatory region DNA binding
poly(A) RNA binding
G-quadruplex DNA binding
nucleotide binding
nucleic acid binding
DNA binding
RNA binding
helicase activity
ATP-dependent helicase activity
hydrolase activity
RNA helicase
ossification
transcription, DNA-templated
RNA processing
response to virus
RNA secondary structure unwinding
positive regulation of telomere maintenance
positive regulation of type I interferon production
response to exogenous dsRNA
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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