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Proteintech
DIABLO Polyclonal Antibody
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Product Details
10434-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DIABLO Fusion Protein Ag0696 (1-239 aa encoded by BC011909)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes all the three isoforms (27 kDa and 22 kDa) of DIABLO. The highest expression was in the testis, adrenal gland, and ears.
Immunogen sequence: MAALKSWLS RSVTSFFRYR QCLCVPVVAN FKKRCFSELI RPWHKTVTIG FGVTLCAVPI AQKSEPHSLS SEALMRRAVS LVTDSTSTFL SQTTYALIEA ITEYTKAVYT LTSLYRQYTS LLGKMNSEEE DEVWQVIIGA RAEMTSKHQE YLKLETTWMT AVGLSEMAAE AAYQTGADQA SITARNHIQL VKLQVEEVHQ LSRKAETKLA EAQIEELRQK TQEEGEERAE SEQEAYLRED (1-239 aa encoded by BC011909)
Target Information
DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms. Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: antagonist of IAPs (inhibitors of apoptosis); diablo homolog (Drosophila) isoform DIABLO_1; diablo homolog (Drosophila) isoform DIABLO_2; Diablo homolog, mitochondrial; Diablo IAP-binding mitochondrial protein; diablo-like protein; DIABLO-S; direct IAP binding protein with low PI; Direct IAP-binding protein with low pI; FLJ10537; FLJ25049; hCG_1782202; Second mitochondria-derived activator of caspase; Second mitochondria-derived activator of caspases; short isoform; SMAC; Smac protein; SMAC3; unnamed protein product
Gene Aliases: 0610041G12Rik; 1700006L01Rik; AU040403; DFNA64; DIABLO; SMAC
UniProt ID: (Human) Q9NR28, (Mouse) Q9JIQ3
Entrez Gene ID: (Human) 56616, (Mouse) 66593, (Rat) 288753
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
intrinsic apoptotic signaling pathway in response to oxidative stress
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
positive regulation of apoptotic process
neuron apoptotic process
intrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway via death domain receptors
apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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