Immunogen sequence: PMIGFAHGQI NFFKKGAEMF SKRMDSFLSS VADMVQSIQV ELEAEAEKMR VSQQELLSVD ESVYTPDSDV AAPQINRNLI QK
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 90%.
Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Adapter protein containing PH domain, PTB domain and leucine zipper motif 2; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; DCC-interacting protein 13-beta; DIP13 beta; Dip13-beta
Gene Aliases: APPL2; DIP13B
UniProt ID: (Human) Q8NEU8
Entrez Gene ID: (Human) 55198
Molecular Function: scaffold/adaptor protein