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Proteintech
DIS3 Polyclonal Antibody
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Product Details
14689-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Fruit fly,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DIS3 Fusion Protein Ag6117 (607-958 aa encoded by BC056143)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TTSLRGLNK LAKILKKRRI EKGALTLSSP EVRFHMDSET HDPIDLQTKE LRETNSMVEE FMLLANISVA KKIHEEFSEH ALLRKHPAPP PSNYEILVKA ARSRNLEIKT DTAKSLAESL DQAESPTFPY LNTLLRILAT RCMMQAVYFC SGMDNDFHHY GLASPIYTHF TSPIRRYADV IVHRLLAVAI GADCTYPELT DKHKLADICK NLNFRHKMAQ YAQRASVAFH TQLFFKSKGI VSEEAYILFV RKNAIVVLIP KYGLEGTVFF EEKDKPNPQL IYDDEIPSLK IEDTVFHVFD KVKVKIMLDS SNLQHQKIRM SLVEPQIPGI SIPTDTSNMD LNGPKKKKMK LGK (607-958 aa encoded by BC056143)
Target Information
The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bA555G22.1; DIS3 exosome endoribonuclease and 3'-5' exoribonuclease; DIS3 mitotic control homolog; Exosome complex exonuclease RRP44; exosome component 11; mitotic control protein dis3 homolog; Protein DIS3 homolog; Ribosomal RNA-processing protein 44; RP11-342J4.3
Gene Aliases: 2810028N01Rik; DIS3; dis3p; EXOSC11; KIAA1008; RGD1304646; RRP44
UniProt ID: (Human) Q9Y2L1, (Mouse) Q9CSH3
Entrez Gene ID: (Human) 22894, (Mouse) 72662, (Rat) 306103
rRNA processing
mRNA catabolic process
rRNA catabolic process
regulation of mRNA stability
positive regulation of GTPase activity
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
CUT catabolic process
RNA phosphodiester bond hydrolysis, exonucleolytic
nucleic acid phosphodiester bond hydrolysis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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