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Bethyl Laboratories
DIS3 Polyclonal Antibody
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FIGURE: 1 / 1
DIS3 Antibody (A303-766A) in WB
Detection of human DIS3 by western blot and immunoprecipitation. Samples: Whole cell lysate from HeLa (15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded), HEK293T (T; 50 µg) and Jurkat (J; 50 µg) cells. Antibodies: Affinity purified rabbit anti-DIS3 antibody (Product # A303-766A) used for WB at 0.1 µg/mL (A) and 1 µg/mL (B) and used for IP at 6 µg/mg lysate. DIS3 was also immunoprecipitated by rabbit anti-DIS3 antibodies A303-764A and A303-765A, which recognize upstream epitopes. Detection: Chemiluminescence with exposure times of 30 seco... View More
Product Details
A303-766A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 908 and 958 of human DIS3 mitotic control homolog.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bA555G22.1; DIS3 exosome endoribonuclease and 3'-5' exoribonuclease; DIS3 mitotic control homolog; Exosome complex exonuclease RRP44; exosome component 11; mitotic control protein dis3 homolog; Protein DIS3 homolog; Ribosomal RNA-processing protein 44; RP11-342J4.3
Gene Aliases: 2810028N01Rik; DIS3; dis3p; EXOSC11; KIAA1008; RRP44
UniProt ID: (Human) Q9Y2L1
Entrez Gene ID: (Human) 22894
rRNA processing
mRNA catabolic process
rRNA catabolic process
regulation of mRNA stability
positive regulation of GTPase activity
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
CUT catabolic process
RNA phosphodiester bond hydrolysis, exonucleolytic
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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