Proteintech

DIS3L2 Polyclonal Antibody

View all (12) DIS3L2 antibodies

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Questions & Answers

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DIS3L2 Antibody in Western Blot (WB) — Mouse embryo tissue were subjected to SDS PAGE followed by western blot with 25792-1-AP (DIS3L2 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

DIS3L2 Antibody in Western Blot (WB) — HepG2 cells were subjected to SDS PAGE followed by western blot with 25792-1-AP ( DIS3L2 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

Product Details

25792-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	-

Product Specifications
Species Reactivity	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	DIS3L2 Fusion Protein Ag22963 (1-170 aa encoded by BC030113) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.17 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: AGALGYRER LDMAPDTLQK QADHCNDSRM ASKRVQELST SLFFAVLVKE SGPLESEAMV MGILKQAFDV LVLRYGVQKR IYCNALALRS HHFQKVGKKP ELTLVWEPED MEQEPAQQVI TIFSLVEVVL QAEYTALKYS AILKRPGTQG HLGPEKEEEE SDGEPEDSST S (1-170 aa encoded by BC030113)

Target Information

DIS3L2 encodes a protein that is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DIS3 mitotic control homolog-like 2; DIS3-like exonuclease 2; DIS3L2; family with sequence similarity 6, member A; hDIS3L2

Gene Aliases: 4930429A22Rik; 8030493P09Rik; DIS3L2; FAM6A; hDIS3L2; PRLMNS

UniProt ID: (Human) Q8IYB7, (Mouse) Q8CI75

Entrez Gene ID: (Human) 129563, (Mouse) 208718

Molecular Function: exoribonuclease

nuclear-transcribed mRNA catabolic process, exonucleolytic rRNA processing mitotic nuclear division negative regulation of cell proliferation miRNA catabolic process rRNA catabolic process stem cell population maintenance nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' cell division mitotic sister chromatid separation RNA phosphodiester bond hydrolysis, exonucleolytic polyuridylation-dependent mRNA catabolic process mRNA catabolic process cell cycle RNA phosphodiester bond hydrolysis

Process(es)

3'-5'-exoribonuclease activity magnesium ion binding ribonuclease activity protein binding poly(U) RNA binding RNA binding nuclease activity exonuclease activity 5'-3' exoribonuclease activity hydrolase activity metal ion binding