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Invitrogen
DKC1 Polyclonal Antibody
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Product Details
PA5-101068
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DKC1(Accession O60832), corresponding to amino acid residues R183-L233.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total DKC1.
Target Information
This gene is a member of the H/ACA snoRNPs gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases. Mutations in this gene also cause Hoyeraal-Hreidarsson syndrome, which is a more severe form of dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CBF5 homolog; dyskeratosis congenita 1, dyskerin; dyskeratosis congenita 1, dyskerin homolog; Dyskerin; H/ACA ribonucleoprotein complex subunit 4; H/ACA ribonucleoprotein complex subunit 4 isoform 3; H/ACA ribonucleoprotein complex subunit DKC1; Nopp140-associated protein of 57 kDa; nucleolar protein; Nucleolar protein family A member 4; Nucleolar protein NAP57; snoRNP protein DKC1
Gene Aliases: BC068171; CBF5; CHINE1; DKC; DKC1; DKCX; NAP57; NOLA4; XAP101
UniProt ID: (Human) O60832, (Rat) P40615, (Mouse) Q9ESX5
Entrez Gene ID: (Human) 1736, (Rat) 170944, (Mouse) 245474
telomerase activity
RNA binding
protein binding
pseudouridine synthase activity
isomerase activity
box H/ACA snoRNA binding
telomerase RNA binding
poly(A) RNA binding
pivalyl-CoA mutase activity
o-hydroxylaminobenzoate mutase activity
lupeol synthase activity
beta-amyrin synthase activity
baruol synthase activity
centromere DNA-binding protein
chromatin/chromatin-binding, or -regulatory protein
enzyme-directed rRNA pseudouridine synthesis
box H/ACA snoRNA 3'-end processing
pseudouridine synthesis
rRNA processing
RNA processing
telomere maintenance via telomerase
RNA modification
rRNA pseudouridine synthesis
snRNA pseudouridine synthesis
positive regulation of telomere maintenance via telomerase
box H/ACA snoRNA metabolic process
ribosome biogenesis
scaRNA localization to Cajal body
telomerase RNA stabilization
protein localization to Cajal body
regulation of telomerase RNA localization to Cajal body
positive regulation of telomerase RNA localization to Cajal body
telomerase holoenzyme complex assembly
mRNA pseudouridine synthesis
RNA-dependent DNA biosynthetic process
cell proliferation
positive regulation of telomerase activity
rRNA modification
DNA biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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