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DKK1 Polyclonal Antibody

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DKK1 Polyclonal Antibody

Product Details

BS-2162R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:100
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Dog, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human DKK1, amino acids 201-266.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play important regulatory roles in the Wnt/beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/beta-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/beta-catenin signaling cascade. It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: dickkopf 1 homolog; dickkopf homolog 1; Dickkopf-1; dickkopf-1 like; dickkopf-like protein 1; Dickkopf-related protein 1; Dickkopf1; dkk-1; hDkk1; secreted wnt inhibitor with affinity for heparin sepharose; SK; unnamed protein product

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Gene Aliases: DKK-1; DKK1; mdkk-1; SK; UNQ492/PRO1008

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UniProt ID: (Human) O94907, (Mouse) O54908

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Entrez Gene ID: (Human) 22943, (Dog) 609600, (Mouse) 13380, (Rat) 293897

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Function(s)
protein binding growth factor activity co-receptor binding receptor antagonist activity low-density lipoprotein particle receptor binding molecular_function
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis endoderm formation mesoderm formation hair follicle development regulation of receptor internalization heart induction heart valve development endocardial cushion development endoderm development learning or memory positive regulation of gene expression negative regulation of neuron projection development Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of Wnt signaling pathway negative regulation of ossification embryonic limb morphogenesis negative regulation of BMP signaling pathway forebrain development response to retinoic acid negative regulation of mesodermal cell fate specification regulation of endodermal cell fate specification negative regulation of apoptotic process regulation of neuron apoptotic process positive regulation of Wnt signaling pathway, calcium modulating pathway positive regulation of JNK cascade regulation of synapse organization regulation of synaptic transmission, glutamatergic canonical Wnt signaling pathway limb development head morphogenesis face morphogenesis negative regulation of SMAD protein import into nucleus motor learning negative regulation of canonical Wnt signaling pathway Wnt signaling pathway involved in somitogenesis synapse pruning regulation of dopaminergic neuron differentiation negative regulation of Wnt-Frizzled-LRP5/6 complex assembly positive regulation of midbrain dopaminergic neuron differentiation negative regulation of presynapse assembly positive regulation of Wnt signaling pathway, planar cell polarity pathway negative regulation of cardiac muscle cell differentiation cell morphogenesis involved in differentiation multicellular organism development negative regulation of protein complex assembly negative regulation of peptidyl-serine phosphorylation negative regulation of skeletal muscle tissue development negative regulation of pathway-restricted SMAD protein phosphorylation positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway extracellular negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment negative regulation of receptor activity
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